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merck millipore,默克密理博,AB15928,Anti-Vitamin K dependent protein S Antibody
产品名称：Anti-Vitamin K dependent protein S Antibody
产品型号：AB15928
Detect Vitamin K dependent protein S using this Anti-Vitamin K dependent protein S Antibody validated for use in WB.
merck millipore,默克密理博,AB15928,Anti-Vitamin K dependent protein S Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, M, H, Eq, Chp, Mk, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15928 描述 Anti-Vitamin K dependent protein S Antibody Alternate Names - vitamin K-dependent plasma protein S
- protein S (alpha)
- protein S, alpha
- protein Sa
背景信息 Vitamin K dependent protein S is an anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. 产品信息 格式 Affinity Purified 控制 - Mouse liver tissue lysate
演示 Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. 应用 应用 Detect Vitamin K dependent protein S using this Anti-Vitamin K dependent protein S Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Immunoprecipitation Analysis: 1:50,000 dilution from a previous lot detected Vitamin K dependent protein S on 15 µg of normal mouse serum. 生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide corresponding to residues surrounding the mature peptide region of Vitamin K dependent protein S. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Vitamin K dependent protein S. 品种反应性 Rhesus MacaqueMouseHumanHorseChimpanzeeMonkeyRat Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human, horse and chimpanzee. Monkey (93%) and Rat (93%) Rhesus Monkey (93%). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000304.2
Entrez基因汇总 This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. 基因符号 - PSA
- PROS
- PS21
- PS22
- PS23
- PS24
- PS25
纯化方法 Affinity Purfied UniProt编号 - P07225
UniProt汇总 FUNCTION: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Plasma.
PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.
INVOLVEMENT IN DISEASE: Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
SEQUENCE SIMILARITIES: Contains 4 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 2 laminin G-like domains.
SEQUENCE CAUTION: The sequence AAP45054.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in mouse liver tissue lysate.
Western Blot Analysis: : 1:1000 dilution of this antibody detected Vitamin K dependent protein S on 10 µg of mouse liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for 1 year from date of receipt. 包装信息 数量 100 µg
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