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Replacement Information Replacement Information 05-1424 is a recommended replacement for MAB2152 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ELISA, WB, IHC, ICC, FC M Purified Monoclonal Antibody 描述 产品目录编号 05-1424 Replaces MAB2152 描述 Anti-Endoglin Antibody, clone P3D1 Alternate Names - Ancillary TGF-beta Receptor
- CD105
背景信息 Endoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 Purified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6 应用 应用 Anti-Endoglin Antibody, clone P3D1 is an antibody against Endoglin for use in WB, IH, IC, IP, FC, ELISA. 主要应用 - ELISA
- Western Blotting
- Immunohistochemistry
- Immunocytochemistry
- Flow Cytometry
应用说明 Immunohistochemistry: For use on acetone or paraformaldehyde fixed tissue.
ELISA: A previous lot of this antibody was used in ELISA.
Immunoprecipitation: A previous lot of this antibody was used in IP.
Immunocytochemistry: A previous lot of this antibody was used in IC.
Flow Cytometry: A previous lot of this antibody was used in FC.
Optimal working dilutions must be determined by the end user.
生物信息 免疫原品种 Human resting umbilical vein endothelial cells. 克隆 P3D1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with human endoglin. 同种型 IgG2a 品种反应性 RatHumanMouse Species Reactivity Note Human and mouse. Expected to react with rat based on sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000118.1
Entrez基因汇总 Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - endoglin
- ENG
- ORW
- CD105
- HHT1
- END
- FLJ41744
- ORW1
纯化方法 Purified UniProt编号 - P17813
UniProt汇总 FUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
SIZE: 658 amino acids; 70578 Da
SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.产品使用声明 质量保证 Routinely evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable at 2-8°C for up to 1 year from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,07-585,Anti-dimethyl-Histone H3 (Arg2) Antibody
下一件merck millipore产品：merck millipore,默克密理博,03-115,RIPAb+ Musashi 2 - RIP Validated Antibody and Primer Set, rabbit monoclonal
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