merck millipore,默克密理博,MABN489,Anti-GABA(A)R, Alpha1 Protein Antibody, clone N95/35

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, M	IHC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN489
描述	Anti-GABA(A)R, Alpha1 Protein Antibody, clone N95/35
Alternate Names	GABA(A) receptor subunit alpha-1 Gamma-aminobutyric acid receptor subunit alpha-1
背景信息	The neurotransmitter GABA (gamma-aminobutyric acid) binds to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. Three general classes of GABA receptors are known: GABAA and GABAC (ionotropic) receptors and GABAB (metabotropic) receptors. The GABAA (gamma-Aminobutyric Acid type A) receptor is a multiprotein complex that acts as a ligand-gated chloride channel. These receptors are hetero-oligomers, for which 6 subunits are currently known (a, b, g, d, e and r). There are at least 6 different isoforms of the alpha subunit, and receptor subunit expression varies during development. Increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents observed during postnatal development. Additionally, alpha1-containing GABAA receptors are important in regulating the reinforcing properties of alcohol, and expression of the alpha1 subunit increases upon chronic exposure to alcohol, making it a potential therapeutic target for alcohol dependency.

产品信息
格式	Purified
控制	Mouse brain tissue lysate
演示	Purified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-GABA(A)R, Alpha1 Protein Antibody, clone N95/35 is validated for use in Western Blotting, IHC for the detection of GABA(A)R, Alpha1 Protein, clone N95/35.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A representative lot detected GABA(A)R, Alpha1 Protein in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis). Western Blot Analysis: A representative lot detected GABA(A)R, Alpha1 Protein in RBM membrane extracts, COS cell lysates transiently transfected with GABA(A)R, Alpha1 Protein, and in WT mice but not in GABA(A)R Alpha1 knockout mice.

生物信息
免疫原品种	Recombinant protein corresponding to the cytoplasmic domain of mouse GABA(A)R, Alpha1 Protein.
表位	Cytoplasmic domain
克隆	N95/35
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody recognizes the cytoplasmic domain of GABA(A)R, Alpha1 Protein. This antibody does not demonstrate cross-reactivity against GABA(A)R2 and GABA(A)R3 (Prof. J. Trimmer, University of California, Davis).
同种型	IgG_2a
品种反应性	RatMouse
Species Reactivity Note	Demonstrated to react with Mouse and Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_034380
基因符号	Gabra-1 Gabra1
纯化方法	Protein G purified
UniProt编号	P62812

产品使用声明
质量保证	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blot Analysis: 2 µg/mL of this antibody detected GABA(A)R, Alpha1 Protein in 10 µg of mouse brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN489,Anti-GABA(A)R, Alpha1 Protein Antibody, clone N95/35

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