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品种反应性 主要应用 宿主 格式 抗体类型 R, B, Gt, H IHC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB1763 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neurogranin Antibody Alternate Names - B50-immunoreactive C-Kinase Substrate
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide. 应用 应用 Detect Neurogranin using this Anti-Neurogranin Antibody validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot: 1:1,000 (using ECL)
Immunohistochemistry: 1:1,000 The antibody has been used successfully on paraformaldehyde-fixed cryostat or Vibratome sections.
Immunoprecipitation: 1:250 on perchloric acid-treated brain homogenates using Protein A-Agarose to precipitate the immune complex.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A synthetic peptide corresponding to amino acid residues 9-25 of the rat neurogranin protein. 宿主 Rabbit 特异性 Neurogranin is a 78 amino acid neuron-specific substrate of protein kinase C that accumulates predominantly in dendritic shafts and spines of neurons. Immunoreactive neurogranin has been detected in many brain regions but is particularly abundant in the mammaliam forebrain. Immunostaining is completely abolished by pre-adsorption of the antibody with the immunogen peptide. 品种反应性 RatBovineGoatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006176.1
Entrez基因汇总 Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. 基因符号 - hng
- NRGN
- neurogranin
- Ng
- Neurogranin
- RC3
UniProt编号 - Q92686
UniProt汇总 FUNCTION: SwissProt: Q92686 # Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
SIZE: 78 amino acids; 7618 Da
SIMILARITY: SwissProt: Q92686 ## Belongs to the neurogranin family. & Contains 1 collagen-like domain. & Contains 1 IQ domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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