merck millipore,默克密理愽
  • merck millipore,默克密理博,227016,CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

  • merck millipore,默克密理博,227016,CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

    产品名称：CCR2 Antagonist - CAS 445479-97-0 - Calbiochem
    产品型号：227016
    The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

    merck millipore,默克密理博,227016,CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,227016,CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₈H₃₄F₃N₅O₄S445479-97-0
    描述
    概述 A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
    产品目录编号 227016
    品牌系列 Calbiochem®
    同义词 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
    参考
    参考 Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.
    产品信息
    CAS号 445479-97-0
    形式 White solid
    Hill配方 C₂₈H₃₄F₃N₅O₄S
    化学配方 C₂₈H₃₄F₃N₅O₄S
    Molar Mass 593.7
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC (racemic mixture)
    理化信息
    溶解度 DMSO or EtOH
    安全信息
    S相 S: 22-24/25-36/37/39

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,227016,CCR2 Antagonist - CAS 445479-97-0 - Calbiochem

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