merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN471,Anti-Tau Antibody, PAD, clone TNT-1

  • merck millipore,默克密理博,MABN471,Anti-Tau Antibody, PAD, clone TNT-1

    产品名称：Anti-Tau Antibody, PAD, clone TNT-1
    产品型号：MABN471
    Anti-Tau, PAD, clone TNT-1 detects levels of Tau proteins & has been published & validated for use in WB, IHC, IF & ELISA.

    merck millipore,默克密理博,MABN471,Anti-Tau Antibody, PAD, clone TNT-1

  • 产品介绍
  • merck millipore,默克密理博,MABN471,Anti-Tau Antibody, PAD, clone TNT-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN471
    Replaces MAB10417
    描述 Anti-Tau Antibody, PAD, clone TNT-1
    Alternate Names
    • Tau, phosphatase activating domain
    • Microtubule-associated protein tau
    • Neurofibrillary tangle protein
    • Paired helical filament-tau
    • PHF-tau
    背景信息 Tau or Microtubule-associated protein tau (MAPT), also known as neurofibrillary tangle protein and paired helical filament-tau (PHF-tau), is a cytosolic protein that promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of axonal polarity in neurons. Tau binds to and is thought to function as a linker protein between axonal microtubules and neural plasma membrane components. There are multiple isoforms, and the short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PAD is the phosphatase activating domain, and has been demonstrated to be involved in the inhibition of anterograde, kinesin-based fast axonal transport (FAT) by activating axonal protein phosphatase 1 (PP1) and glycogen synthase kinase 3 (GSK3), independent of microtubule binding. Defects in Tau are thought to be the cause of a number of neurodegenerative diseases, including frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND), Pick disease of the brain (PIDB), corticobasal degeneration (CBD), supranuclear palsy type 1 (PSNP1), Alzheimer disease, and Parkinson disease.
    产品信息
    格式 Purified
    控制
    • rat cortex tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Tau, PAD, clone TNT-1 detects levels of Tau proteins & has been published & validated for use in WB, IHC, IF & ELISA.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: 1 µg/mL from a representative lot detected Tau, PAD in 10 µg of human and mouse cortex tissue lysates.

    Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Tau, PAD in human Alzheimer's brain tissue.

    Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Tau, PAD in normal and Alzheimer's tissues from entorhinal cortex, hippocampus, inferior temporal gyrus, and superior gyrus of control (Kanaan, N. M., et al. (2011). J Neurosci. 31(27):9858-9868.).

    ELISA Analysis: A representative lot from an independent laboratory detected Tau, PAD in recombinant Tau protein (Kanaan, N. M., et al. (2011). J Neurosci. 31(27):9858-9868.).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Tau.
    克隆 TNT-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001116538
    基因符号
    • TAU
    • MAPT
    • MAPTL
    • MTBT1
    纯化方法 Protein G purified
    UniProt编号
    • P10636
    产品使用声明
    质量保证 Evaluated by Western Blot in rat cortex tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Tau, PAD in 10 µg of rat cortex tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN471,Anti-Tau Antibody, PAD, clone TNT-1

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下一件merck millipore产品：merck millipore,默克密理博,04-592,Anti-Flotillin-1 Antibody, rabbit monoclonal, clone EP446Y


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