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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB16530 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-BAFF Antibody, CT Alternate Names - BLyS
- TALL-1
- THANK
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-BAFF Antibody, C-terminus detects level of BAFF & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.25 to 1 μg/mL.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-BAFF (C-term) polyclonal antibody was raised against a peptide corresponding to amino acids 254 to 269 of human BAFF (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999). 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BlyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal kinase) (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999). BAFF/BlyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion (Moore et al. 1999; Schneider et al. 1999). Two receptors for BAFF were recently identified and designated TACI and BCMA (Gross et al. 2000). BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases (Gross et al. 2000; Khare et al. 2000). Like TNFalpha and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis (Mukhopadhyay et al. 1999). 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006573.3
Entrez基因汇总 The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. 基因符号 - BLYS
- TNFSF13B
- BLyS
- TNFSF20
- CD257
- BAFF
- TALL1
- DTL
- TALL-1
- ZTNF4
- THANK
UniProt编号 - Q9Y275
UniProt汇总 FUNCTION: SwissProt: Q9Y275 # Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
SIZE: 285 amino acids; 31223 Da
SUBUNIT: Homotrimer.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
PTM: The soluble form derives from the membrane form by proteolytic processing. & N-glycosylated.
SIMILARITY: SwissProt: Q9Y275 ## Belongs to the tumor necrosis factor family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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