merck millipore,默克密理博,04-592,Anti-Flotillin-1 Antibody, rabbit monoclonal, clone EP446Y

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-592
品牌系列	Upstate
商名	Upstate
描述	Anti-Flotillin-1 Antibody, rabbit monoclonal, clone EP446Y
Alternate Names	Reggie-2
背景信息	Flotillin-1, also known as Reggie-2, belongs to a larger family of proteins that share an evolutionarily conserved stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (1). Flotillin-1 is a lipid raft-associated protein that has been implicated in various cellular processes. Flotillin was first found in cells that lack morphologically definable caveolae, as well as in non-caveolar membranes (2) and was subsequently identified in low density detergent-insoluble complexes of endothelial cells, where they were termed flotillins (3). As well as its postulated role in neuronal regeneration, flotilllin-1 has been implicated in insulin signaling to trigger glucose transporter redistribution in adipocytes (4) Flotillin also associates with phagosomes in macrophages (5).

产品信息
格式	Purified
演示	Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Flotillin-1 Antibody, Rabbit, clone EP446Y is validated for use in WB for the detection of Flotillin-1.
主要应用	Western Blotting
应用说明	WB: 1:500

生物信息
免疫原品种	A synthetic peptide corresponding to residues in human Flotillin-1.
克隆	EP446Y
宿主	Rabbit
特异性	Recognizes Human, Mouse Flotillin-1.
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse (positive control: K562 cell lysate)
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_005803.2
Entrez基因汇总	Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.
基因符号	Flotillin-1. FLOT1
纯化方法	Protein A purfied
UniProt编号	O75955
UniProt汇总	FUNCTION: SwissProt: O75955 # May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. SIZE: 427 amino acids; 47355 Da SUBUNIT: Hetero-oligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). SUBCELLULAR LOCATION: Cell membrane, caveola; Peripheral membrane protein. Melanosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. SIMILARITY: SwissProt: O75955 ## Belongs to the band 7/mec-2 family. Flotillin subfamily.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at -20 °C. Stable for 12 months from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,04-592,Anti-Flotillin-1 Antibody, rabbit monoclonal, clone EP446Y

相关产品

merck millipore,默克密理博,9081,Human Leptin

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech