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merck millipore,默克密理博,MABN457,Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1
产品名称：Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1
产品型号：MABN457
Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1 is a highly specific mouse monoclonal antibody, that targets Solute carrier family 25 member 10 & has been tested in western blotting & I More>>
merck millipore,默克密理博,MABN457,Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN457 描述 Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1 Alternate Names - Solute carrier family 25 member 10
- Mitochondrial dicarboxylate carrier
背景信息 The protein named Mitochondrial dicarboxylate carrier or Solute carrier family 25 member 10, or Dicarboxylate Carrier Slc25a10 and encoded by the gene named SLC25A10 or DIC is a mitochondrial transport protein that mediates the transfer of malonate, malate, and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across the mitochondrial inner membrane. These components are critical for the function of the Krebs cycle, as well as gluconeogenesis, urea and sulfur metabolism. Mitochondrial dicarboxylate carrier is expressed in high amounts in the liver and kidney and at lower levels in all other tissues and is localized to the mitochondria and specifically to the inner mitochondrial membrane. Mitochondrial dicarboxylate carrier is also upregulated in various tissues in response to free fatty acids particularly in adipose tissues, and plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells. Impairment of Mitochondrial dicarboxylate carrier is associated with ethylmalonic encephalopathy (EE) and short chain acyl-CoA dehydrogenase deficiency (SCADD) syndromes. Research indicates that it is the buildup of ethylmalonic acid in the tissues that impairs the Succinate and malate uptake by Mitochondrial dicarboxylate carrier leading to metabolic distress and dysfunction. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Mitochondrial dicarboxylate carrier Antibody, clone 1F5.1 is a highly specific mouse monoclonal antibody, that targets Solute carrier family 25 member 10 & has been tested in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Mitochondrial dicarboxylate carrier in human kidney and human liver tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Mitochondrial dicarboxylate carrier. 克隆 1F5.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001257817
基因符号 - DIC
- SLC25A10
纯化方法 Protein G purified UniProt编号 - Q9UBX3
产品使用声明 质量保证 Evaluated by Western Blotting in mouse liver tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Mitochondrial dicarboxylate carrier in 200 µg of mouse liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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