merck millipore,默克密理博,658425,AG 17 - CAS 10537-47-0

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merck millipore,默克密理博,658425,AG 17 - CAS 10537-47-0 - Calbiochem
产品名称：AG 17 - CAS 10537-47-0 - Calbiochem
产品型号：658425
Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM).

merck millipore,默克密理博,658425,AG 17 - CAS 10537-47-0 - Calbiochem

产品介绍

merck millipore,默克密理博,658425,AG 17 - CAS 10537-47-0 - Calbiochem

重要规格表

经验配方	CAS号
C₁₈H₂₂N₂O	10537-47-0

描述
概述	Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
产品目录编号	658425
品牌系列	Calbiochem®
同义词	NSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872

参考
参考	Fuortes, M., et al. 1999. J. Clin. Invest. 104, 327. Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434. Burger, A.M., et al. 1995. Cancer Res. 55, 2794. Palumbo, G.A., et al. 1994. Blood 84, 296a. Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721. Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171. Terada, H. 1981. Biochim. Biophys. Acta 639, 225

参考

Fuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
Palumbo, G.A., et al. 1994. Blood 84, 296a.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
Terada, H. 1981. Biochim. Biophys. Acta 639, 225

产品信息
CAS号	10537-47-0
具有ATP竞争性	Y
形式	Pale yellow solid
Hill配方	C₁₈H₂₂N₂O
化学配方	C₁₈H₂₂N₂O
Molar Mass	282.4
可逆	Y
结构配方图像

生物信息
主靶	Platelet-derived growth factor receptor tyrosine kinase
主靶IC₅₀	500 nM against platelet-derived growth factor receptor tyrosine kinase
纯度	≥99% by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

GHS安全信息
RTECS	OO3737000

安全信息
R相	R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
S相	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.