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merck millipore,默克密理博,567417,SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
产品名称：SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
产品型号：567417
The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.
merck millipore,默克密理博,567417,SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₁H₈Cl₂N₂O 41931-13-9 描述 概述 A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes. 产品目录编号 567417 品牌系列 Calbiochem®
同义词 lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor 参考 参考 Somwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176产品信息 CAS号 41931-13-9 形式 White solid Hill配方 C₁₁H₈Cl₂N₂O 化学配方 C₁₁H₈Cl₂N₂O Molar Mass 255.1 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,658425,AG 17 - CAS 10537-47-0 - Calbiochem
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