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merck millipore,默克密理博,203882,CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
产品名称：CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
产品型号：203882
A cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor.
merck millipore,默克密理博,203882,CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₉N₇O 1084893-56-0 描述 概述 A cell-permeable (R)-DRF053 (Cat. No. 219494) analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC50 = 0.15, 0.080, 0.060, 0.12, 0.11, and 0.61 µM against CDK1/B, CDK2/A, CDK2/E, CDK5/p25, CDK9/T, and CK1δ/ε, respectively). Although (S)-CR8 displays in general similar kinase inhibitory profile as its (R)-enantiomer (Cat. No. 203881), it does exhibit more enhanced and reduced activity against, respectively, Dyrk1A (IC50 = 0.9 µM) and GSK-3α/β (IC50 ≥ 30 µM). Both (R)- and (S)-CR8 are much more effective than (R)-Roscovitine (Cat. Nos. 550360 and 550364) in apoptosis induction in cell cultures. 产品目录编号 203882 品牌系列 Calbiochem®
同义词 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8 参考 参考 Bettayeb, K., et al. 2008. Oncogene 27, 5797. 产品信息 CAS号 1084893-56-0 形式 Off-white solid Hill配方 C₂₄H₂₉N₇O 化学配方 C₂₄H₂₉N₇O Molar Mass 431.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,524611,PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,442611,Magnesium Chloride, Hexahydrate, Molecular Biology Grade - CAS 7791-18-6 - Calbiochem
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