merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB302,Anti-Glutamine Synthetase Antibody, clone GS-6

  • merck millipore,默克密理博,MAB302,Anti-Glutamine Synthetase Antibody, clone GS-6

    产品名称：Anti-Glutamine Synthetase Antibody, clone GS-6
    产品型号：MAB302
    Detect Glutamine Synthetase using this Anti-Glutamine Synthetase Antibody, clone GS-6 validated for use in ELISA, IH, IH(P) & WB.

    merck millipore,默克密理博,MAB302,Anti-Glutamine Synthetase Antibody, clone GS-6

  • 产品介绍
  • merck millipore,默克密理博,MAB302,Anti-Glutamine Synthetase Antibody, clone GS-6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sh, H, M, RWB, ELISA, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB302
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glutamine Synthetase Antibody, clone GS-6
    背景信息 Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 45 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.
    产品信息
    格式 Purified
    控制
    • Rat brain tissue, rat brain cytosolic fraction extract
    演示 Purified immunoglobulin. Liquid in buffer containing 50% glycerol, BSA and 0.09% sodium azide.
    应用
    应用 Detect Glutamine Synthetase using this Anti-Glutamine Synthetase Antibody, clone GS-6 validated for use in ELISA, IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunohistochemistry
    应用说明 Western blot: 1:1,000-1:5,000

    Immunohistochemistry on rat brain

    ELISA

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Glutamine synthetase purified from sheep brain.
    克隆 GS-6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts strongly with a single band on Western blots of sheep brain and rat brain. Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina. Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.
    同种型 IgG2a
    品种反应性 SheepHumanMouseRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001033044.1
    Entrez基因汇总 Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).[supplied by OMIM]
    基因符号
    • GLNS
    • GLUL
    纯化方法 Protein A purfied
    UniProt编号
    • P15104
    UniProt汇总 FUNCTION: SwissProt: P15104 # Catalyzes the conversion of ammonia and L-glutamate to L-glutamine.
    SIZE: 373 amino acids; 42064 Da
    SUBUNIT: Homooctamer.
    SUBCELLULAR LOCATION: Cytoplasm.
    DISEASE:SwissProt: P15104 # Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
    SIMILARITY: SwissProt: P15104 ## Belongs to the glutamine synthetase family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain antibody at 2–8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze-thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB302,Anti-Glutamine Synthetase Antibody, clone GS-6

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下一件merck millipore产品：merck millipore,默克密理博,234491,InSolution™ PD 153035 - Calbiochem


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