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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB, ICC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15414 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MAP1LC3 C Antibody Alternate Names - Microtubule-associated proteins 1A/1B light chain 3C, MAP1A/1B LC3 C, MAP1 LC3, LC3 C
- Microtubule-associated proteins 1A/1B light chain 3C
- MAP1A/1B LC3 C
- MAP1 LC3
背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. The human MAP1LC3 protein is homologous with the rat Map1LC3 and with yeast APG8. These proteins are likely to be involved in the formation of autophagosomal vacuoles (autophagosomes). 产品信息 格式 Serum 演示 Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 This Anti-MAP1LC3 C Antibody is validated for use in WB, IC, IH for the detection of MAP1LC3 C. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to a region within the N-terminus of human MAP1LC3 C protein. 宿主 Rabbit 特异性 MAP1LC3 C [Microtubule-associated proteins 1A/1B light chain 3C, MAP1A/1B LC3 C, MAP1 LC3, LC3 C]. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001004343.1
基因符号 - MAP1LC3C
纯化方法 Serum UniProt编号 - Q9BXW4
UniProt汇总 FUNCTION: SwissProt: Q9BXW4 # Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity).
SIZE: 147 amino acids; 16852 Da
SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid- anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.
TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary.
PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
SIMILARITY: SwissProt: Q9BXW4 ## Belongs to the MAP1 LC3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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