merck millipore,默克密理博,345810,G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2

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merck millipore,默克密理博,345810,G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem
产品名称：G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem
产品型号：345810
G418 also known as Geneticin is an aminoglycoside antibiotic related to Gentamicin. Used as a selective agent in transfection of eukaryotic cells. Has highest potency ≥730 µg/mg and purity ≥98 More>>

merck millipore,默克密理博,345810,G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem

产品介绍

merck millipore,默克密理博,345810,G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem

重要规格表

经验配方	CAS号
C₂₀H₄₀N₄O₁₀ · 2H₂SO₄	108321-42-2

描述
概述	Aminoglycoside related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neo^r/kan^r genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
概述	Also available as a sterile-filtered aqueous solution (Cat. No. 345812), a sterile filtered solution in 100 mM HEPES (Cat. No. 508940), and a sterile-filtered solution PBS (Cat. No. 509227).
产品目录编号	345810
品牌系列	Calbiochem®
同义词	NMD Inhibitor I, G418, G 418

参考
参考	Ethier, S.P., and Taback, E. 1993. Cancer Lett. 74, 189. Santerre, R.F., et al. 1991. Methods Mol. Biol. 7, 245. Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition, Cold Spring Harbor, NY. Edwards, S.A., and Adamson, E.D. 1987. J. Cell Physiol. 133, 46. Ernst, J.F., and Chan, R.K. 1985. J. Bacteriol. 163, 8. Canaani, D., and Berg, P. 1982. Proc. Natl. Acad. Sci. USA 79, 5166. Hirth, K.P., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 7356. Ursic, D., et al. 1981. Biochem. Biophys. Res. Commun. 101, 1031. Jimenez, A., and Davies, J. 1980. Nature 287, 869.

参考

Ethier, S.P., and Taback, E. 1993. Cancer Lett. 74, 189.
Santerre, R.F., et al. 1991. Methods Mol. Biol. 7, 245.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition, Cold Spring Harbor, NY.
Edwards, S.A., and Adamson, E.D. 1987. J. Cell Physiol. 133, 46.
Ernst, J.F., and Chan, R.K. 1985. J. Bacteriol. 163, 8.
Canaani, D., and Berg, P. 1982. Proc. Natl. Acad. Sci. USA 79, 5166.
Hirth, K.P., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 7356.
Ursic, D., et al. 1981. Biochem. Biophys. Res. Commun. 101, 1031.
Jimenez, A., and Davies, J. 1980. Nature 287, 869.

产品信息
CAS号	108321-42-2
形式	White powder
Hill配方	C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
化学配方	C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
Molar Mass	692.7
结构配方图像

生物信息
生物活性	Assay: ≥730 µg/mg
纯度	≥98% by TLC

理化信息
污染物	Ammonia: ≤1.0%; heavy metals: ≤100 ppm
pH值	4.0 -6.0
溶解度	H₂O

GHS安全信息
RTECS	CB9378500

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Following reconstitution, sterilize by filtration through a 0.22 µm or 0.45 µm pore size filter, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Sterile stock solutions are stable for up to 1 year at -20°C.