merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

  • merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

    产品名称：Anti-TIM-3, clone RMT3-23, Azide Free Antibody
    产品型号：MABF230
    This Anti-TIM-3 antibody, clone RMT3-23, Azide Free is validated for use in western blotting, flow cytometry, IHC, ICC & Inhibits activity/Function for the detection of TIM-3.

    merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

  • 产品介绍
  • merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MICC, WB, FC, IHCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABF230
    描述 Anti-TIM-3, clone RMT3-23, Azide Free Antibody
    Alternate Names
    • T-cell membrane protein 3
    • Hepatitis A virus cellular receptor 2 homolog
    • HAVcr-2
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • TIMD-3
    • T-cell immunoglobulin mucin receptor 3
    • TIM-3
    背景信息 The protein called Hepatitis A virus cellular receptor 2 (HAVcr-20), T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3), T-cell immunoglobulin mucin receptor 3 (TIM-3), or T-cell membrane protein 3 and encoded by the human gene HAVCR2/TIM3/TIMD3 is an important protein in the regulation of macrophage activation. TIM-3 is also critical for immune tolerance as it inhibits T-helper type 1 (Th1) mediated auto and alloimmune responses. Finally TIM-3 plays an important role in T-cell homing in the thymus and lymph and is the receptor for the Galectin-9 an important protein modulating cell-cell and cell matrix interactions. TIM-3 is a membrane bound protein that is expressed largely by immune system cells. High TIM-3 expression is also associated with many tumors including renal cancer and acute myelogenous leukemia (AML), and its expression is also a target for anti-cancer therapy as anti-TIM-3 antibodies have been shown to eradicate leukemic stem cells (LSCs) in animal models of AML.
    产品信息
    格式 Purified
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without preservatives.
    应用
    应用 This Anti-TIM-3 antibody, clone RMT3-23, Azide Free is validated for use in western blotting, flow cytometry, IHC, ICC & Inhibits activity/Function for the detection of TIM-3.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Flow Cytometry
    • Immunohistochemistry
    应用说明 Inhibits Activity/Function Assay: Co-administration of a representative lot by an independent laboraotory with FVAX significantly suppressed tumor growth to a greater extent than FVAX alone. Treatment with Anti-TIM-3 , clone RMT3-23, Azide Free also augmented antitumor activities of plasmid DNA encoding melanoma target gp100 or TRP2, suggesting that targeting TIM-3 or TIM-4 improves antitumor activiites of other forms of cancer vaccines. (Bagdadi, M., et al. (2013). Cancer Immunol Immunother. 62(4):629-637.).

    Flow Cytometry Analysis: 1 µg from a representative lot detected TIM-3 in TIM-3 transfected 1X10E6 BALB/L5178Y cells.

    Flow Cytometry Analysis: A representative lot detected TIM-3 in dendritic cells, macrophages, splenocytes, and hepatic mononuclear cells from acute graft-vs-host disease (aGVHD) mice (Oikawa, T., et al. (2006). J Immunol. 177(7):4281-4287.).

    Immunohistochemistry Analysis: A representative lot from an independent laboratory detected TIM-3 in liver tissue from normal and aGVHD mice (Oikawa, T., et al. (2006). J Immunol. 177(7):4281-4287.).

    Immunocytochemistry Analysis: A representative lot from an independent laboratory detected TIM-3 in HMGB1-deficient MEF cells (Chiba, S., et al. (2012). Nat Immunol. 13(9):832-842.).
    生物信息
    免疫原品种 Recombinant protein corresponding to mouse TIM-3.
    克隆 RMT3-23
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_599011
    基因符号
    • Timd3
    • Havcr2
    • Tim3
    纯化方法 Protein G purified
    UniProt编号
    • Q8VIM0
    产品使用声明
    质量保证 Evaluated by Western Blotting in TIM-3 transfected L5178Y cell lysate.

    Western Blotting Analysis: 1 µg/mL of this antibody detected TIM-3 in 10 µg of TIM-3 transfected L5178Y cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

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