merck millipore,默克密理愽
  • merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

  • merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

    产品名称：Z-Guggulsterone - Calbiochem
    产品型号：370690
    A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels.

    merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

    重要规格表

    经验配方
    C₂₁H₂₈O₂
    描述
    概述 A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).
    产品目录编号 370690
    品牌系列 Calbiochem®
    同义词 GS, trans-, trans-4,17(20)-Pregnadiene-3,16-dione
    参考
    参考 Cui, J., et al. 2003. J. Biol. Chem. 278, 10214.
    Urizar, N.L., et al. 2002. Science 296, 1703; Chander, R., et al. 1996. Phytotherapy Res. 10, 508.
    产品信息
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₁H₂₈O₂
    化学配方 C₂₁H₂₈O₂
    Molar Mass 312.5
    可逆 N
    结构配方图像
    生物信息
    主靶 Farnesoid X receptor (FXR)
    主靶IC50 10 µM as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation in the presence of 100 µM chenodeoxycholic acid
    纯度 Single spot by TLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

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