merck millipore,默克密理博,189291,Atorvastatin, Calcium Salt - CAS 134523-03-8

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merck millipore,默克密理博,189291,Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem
产品名称：Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem
产品型号：189291
A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase More>>

merck millipore,默克密理博,189291,Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

产品介绍

merck millipore,默克密理博,189291,Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

重要规格表

经验配方	CAS号
[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2	134523-03-8

描述
概述	A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC₅₀ = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
产品目录编号	189291
品牌系列	Calbiochem®
同义词	(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,

参考
参考	Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press. Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955. Law, M.R., et al. 2003. BMJ 326, 1423. Youssef, S., et al. 2002. Nature 420, 78. Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906. Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057. Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133. Roth, B.D., et al. 1991. J. Med. Chem. 34, 463. Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.

参考

Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
Law, M.R., et al. 2003. BMJ 326, 1423.
Youssef, S., et al. 2002. Nature 420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.

产品信息
CAS号	134523-03-8
形式	White powder
Hill配方	[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
化学配方	[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
Molar Mass	604.7
吸湿	Hygroscopic
结构配方图像

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO, MeOH, or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.