merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

  • merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

    产品名称：Anti-Tumor Necrosis Factor-α Antibody
    产品型号：AB2148P
    Detect Tumor Necrosis Factor-α using this Anti-Tumor Necrosis Factor-α Antibody validated for use in ELISA, NEUT & WB.

    merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2148P
    Replaces AB1450P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tumor Necrosis Factor-α Antibody
    Alternate Names
    • TNF-alpha
    产品信息
    格式 Affinity Purified
    演示 Immunoglobulin purified by affinity chromatography employing immobilized mTNF-alpha matrix. A sterile filtered antibody solution (1mg/mL) was lyophilized from 0.5X PBS, pH 7.2. Reconstitute with sterile distilled water.
    应用
    应用 Detect Tumor Necrosis Factor-α using this Anti-Tumor Necrosis Factor-α Antibody validated for use in ELISA, NEUT & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 ELISA: A concentration of at least 0.5μg/mL (100μL/well) of AB2148P is required to detect 0.2-0.4 ng/well of recombinant mTNF-alpha.

    Western Blot: A concentration of 0.1-0.2 μg/mL of AB2148P is required to detect 1.5-3.0 ng/lane of mTNF-alpha, under either reducing or non-reducing conditions.

    Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of mTNF-a (0.50 ng/ml), a concentration of 0.010-0.015 μg/ml of AB2148P is required.

    Optimal working dilutions must be determined by the end user
    生物信息
    免疫原品种 Highly pure (>98%) recombinant Mouse TNF-alpha.
    宿主 Rabbit
    特异性 Reacts with Mouse Tumor Necrosis Factor-alpha (TNF-alpha), a potent immuno-modulator that mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
    品种反应性 Mouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_038721
    Entrez基因汇总 This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
    基因符号
    • TNF-a
    • TNF
    • TNFSF2
    • Cachectin
    • cachectin
    • DIF
    • TNF-alpha
    • OTTHUMP00000037669
    • TNFA
    UniProt编号
    • P06804
    UniProt汇总 FUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
    SIZE: 233 amino acids; 25644 Da
    SUBUNIT: Homotrimer.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted.
    PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
    DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.
    SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile water to a concentration of = 0.2 mg/mL the antibody is stable for at least six weeks at 2-4ºC.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

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