merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1966,Anti-N-WASP Antibody, phospho-specific [Tyr256]

  • merck millipore,默克密理博,AB1966,Anti-N-WASP Antibody, phospho-specific [Tyr256]

    产品名称：Anti-N-WASP Antibody, phospho-specific [Tyr256]
    产品型号：AB1966
    Anti-N-WASP Antibody, phospho-specific [Tyr256] detects level of N-WASP & has been published & validated for use in ELISA & WB.

    merck millipore,默克密理博,AB1966,Anti-N-WASP Antibody, phospho-specific [Tyr256]

  • 产品介绍
  • merck millipore,默克密理博,AB1966,Anti-N-WASP Antibody, phospho-specific [Tyr256]

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1966
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-N-WASP Antibody, phospho-specific [Tyr256]
    Alternate Names
    • Neural Wiskott-Aldrich Syndrome Protein
    背景信息 Members of the Wiskott-Aldrich sydrome protein (WASP) family regulate the formation of actin-based cell structures in many cell types. These proteins contain C-terminal actin-binding domains that can stimulate actin polymerization. WASP is expressed primarily in hematopoietic cells, while its homolog N-WASP is widely expressed. These proteins have 48% identity in human with higher homology in the functional regions of these proteins. Phosphorylation at serine and tyrosine residues regulates the activity of both proteins. WASP is tyrosine phosphorylated at tyrosine 291 after antigen receptor activation in B-cells and collagen stimulation of platelets. Phosphorylation of the analogous site in N-WASP (Tyr256) stimulates its activity, reduces nuclear N-WASP, and is required for neurite extension.
    产品信息
    格式 Affinity Purified
    演示 This antibody was cross-adsorbed to phosphotyrosine then affinity purified using phospho-N-WASP (Tyr256) peptide (without carrier). Antibody is supplied in 100 μl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
    应用
    应用 Anti-N-WASP Antibody, phospho-specific [Tyr256] detects level of N-WASP & has been published & validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1:10,000 ELISA: 1:20,000
    生物信息
    免疫原品种 Phospho-N-WASP (Tyr256) synthetic peptide (coupled to BSA) corresponding to amino acid residues around tyrosine 256 of human N-WASP. The human WASP sequence has a two amino acid difference in the same region surrounding tyrosine 291.
    表位 phosphotyrosine 256
    宿主 Rabbit
    特异性 The antibody detects a 65 kDa protein corresponding to the molecular weight of phosphorylated N-WASP on SDS-PAGE Western blots of A431 cells treated with pervanadate. A similar band is observed in pervanadate treated HeLa and endothelial cells. Weak bands are also observed at higher molecular weights after pervanadate treatment. These bands may be due to low cross-reactivity with phosphotyrosine.
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003941.2
    Entrez基因汇总 The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
    基因符号
    • NWASP
    • WASL
    • DKFZp779G0847
    • MGC48327
    • N-WASP
    修改
    • Phosphorylation
    UniProt编号
    • O00401
    UniProt汇总 FUNCTION: SwissProt: O00401 # Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
    SIZE: 505 amino acids; 54827 Da
    SUBUNIT: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly.
    SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity).
    SIMILARITY: SwissProt: O00401 ## Contains 1 CRIB domain. & Contains 1 WH1 domain. & Contains 2 WH2 domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 20°C for up to one year from date of receipt. Do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1966,Anti-N-WASP Antibody, phospho-specific [Tyr256]

上一件merck millipore产品：merck millipore,默克密理博,178467,Anti-Apolipoprotein B Goat pAb
下一件merck millipore产品：merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem


相关产品

merck millipore,默克密理博,PRCYTOMAG-40K,MILLIPLEX MAP Non-Human Primate Cytokine Magnetic Bead Panel - Immunology Multiplex Assay merck millipore,默克密理博,PRCYTOMAG-40K,MILLIPLEX MAP Non-Human Primate Cytokine Magnetic Bead Panel - Immu...

merck millipore,默克密理博,S8003,CpGenome™ 5-mC & 5-hmC Human DNA Standards merck millipore,默克密理博,S8003,CpGenome™ 5-mC & 5-hmC Human DNA Standards

merck millipore,默克密理博,676483,VEGFR Tyrosine Kinase Inhibitor IV - CAS 475108-18-0 - Calbiochem merck millipore,默克密理博,676483,VEGFR Tyrosine Kinase Inhibitor IV - CAS 475108-18-0 - Calbiochem

merck millipore,默克密理博,ECM300,QuantiMatrix Human Fibronectin ELISA merck millipore,默克密理博,ECM300,QuantiMatrix Human Fibronectin ELISA

merck millipore,默克密理博,178467,Anti-Apolipoprotein B Goat pAb merck millipore,默克密理博,178467,Anti-Apolipoprotein B Goat pAb

merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem merck millipore,默克密理博,370690,Z-Guggulsterone - Calbiochem

merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody merck millipore,默克密理博,MABF230,Anti-TIM-3, clone RMT3-23, Azide Free Antibody

merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody merck millipore,默克密理博,AB2148P,Anti-Tumor Necrosis Factor-α Antibody

merck millipore,默克密理博,218755,Caspase-4 Inhibitor I - CAS 402832-01-3 - Calbiochem merck millipore,默克密理博,218755,Caspase-4 Inhibitor I - CAS 402832-01-3 - Calbiochem

merck millipore,默克密理博,EZGLU-30K,Glucagon ELISA Kit, Chemiluminescent merck millipore,默克密理博,EZGLU-30K,Glucagon ELISA Kit, Chemiluminescent


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部