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merck millipore,默克密理博,676483,VEGFR Tyrosine Kinase Inhibitor IV - CAS 475108-18-0 - Calbiochem
产品名称：VEGFR Tyrosine Kinase Inhibitor IV - CAS 475108-18-0 - Calbiochem
产品型号：676483
The VEGFR Tyrosine Kinase Inhibitor IV, also referenced under CAS 475108-18-0, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphoryl More>>
merck millipore,默克密理博,676483,VEGFR Tyrosine Kinase Inhibitor IV - CAS 475108-18-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₂H₁₉ClN₄O₅ • H₂O 475108-18-0 描述 概述 A cell-permeable quinoline-urea compound that potently inhibits the kinase activity of VEGFR (IC50 = 30, 6.5, and 15 nM for VEGFR-1,-2,and -3, respectively), EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie-2 (IC50 = 24, 40, 49, 78, and 78 nM, respectively). It exhibits little or no activity towards a panel of 15 other tyrosine kinases, including FGFR, IR, and IGFR, in cell-free kinase assays, while showing more than 7-fold higher potency in inhibiting ligand-induced phosphorylation of VEGFR-1/2/3 vs. c-Kit, PDGFR-β, Flt3, FGFR1, and c-Met in cell-based assays. Shown to be orally available and suppress tumor angiogenesis and growth in rats in vivo. 产品目录编号 676483 品牌系列 Calbiochem®
同义词 N-(2-Chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-Nʹ-(5-methyl-3-isoxazolyl)urea, Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor IV, VEGFR2 Kinase Inhibitor XXI, VEGFR1 Kinase Inhibitor V, VEGFR3 Kinase Inhibitor V, PDGFR Tyrosine Kinase Inhibitor XII 参考 参考 Nakamura, K., et al. 2006. Cancer Res. 66, 9134. 产品信息 CAS号 475108-18-0 具有ATP竞争性 N 形式 Pink solid Hill配方 C₂₂H₁₉ClN₄O₅ • H₂O 化学配方 C₂₂H₁₉ClN₄O₅ • H₂O Molar Mass 472.9 可逆 N 结构配方图像 生物信息 主靶 VEGFR 主靶IC50 30, 6.5, and 15 nM for VEGFR-1,-2, and -3, respectively; 24, 40, 49, 78, and 78 nM for EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie-2, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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