merck millipore,默克密理愽
  • merck millipore,默克密理博,09-258,Anti-phospho-PAK1 (Ser199/Ser204) Antibody

  • merck millipore,默克密理博,09-258,Anti-phospho-PAK1 (Ser199/Ser204) Antibody

    产品名称：Anti-phospho-PAK1 (Ser199/Ser204) Antibody
    产品型号：09-258
    Detect phospho-PAK1 (Ser199/Ser204) using this Anti-phospho-PAK1 (Ser199/Ser204) Antibody validated for use in WB.

    merck millipore,默克密理博,09-258,Anti-phospho-PAK1 (Ser199/Ser204) Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-258,Anti-phospho-PAK1 (Ser199/Ser204) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 09-258
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-PAK1 (Ser199/Ser204) Antibody
    背景信息 p21-activated kinases (PAK) are Ser/Thr kinases, which are activated by, and are effectors of Rho family of GTPases. As such, they are implicated in Actin polymerization and activation of the stress-activated kinase cascades. PAK1 is phosphorylated by cdk5, resulting in its inhibition. PAK2 can be activated by Caspase-cleavage in addition to p21-binding, implicating it in cytoskeletal changes during apoptosis. PAK3 is expressed at high levels in post-mitotic neurons of the developing post-natal cerebral cortex and hippocampus, and is the mutant gene thought responsible for non-syndromic X-linked mental retardation.
    产品信息
    格式 Affinity Purified
    演示 Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol
    应用
    应用 Detect phospho-PAK1 (Ser199/Ser204) using this Anti-phospho-PAK1 (Ser199/Ser204) Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Amino Acids encompassing and including phosphorylated Ser199 and Ser204 of human PAK1. Sequence is highly homologous (greater than 90%) to PAK2 and PAK3.
    表位 Ser199/Ser204 (Central)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes PAK1 phosphorylated on Ser199 and Ser204 (human)/Ser198 and Ser203 (mouse). Immunogen sequence is higly homolgous (greater than 90%) with PAK2 and PAK3.
    品种反应性 Human
    Species Reactivity Note Mouse and Rat expected to react based on 100% homology of immunogen.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002567
    Entrez基因汇总 PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
    基因符号
    • Serine/threonine-protein kinase PAK 1
    • PAK1
    • MGC130001
    • Alpha-PAK
    • MGC130000
    • PAK-1
    • PAKalpha
    • p65-PAK
    • EC 2.7.11.1
    • p21-activated kinase 1
    • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
    • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
    修改
    • Phosphorylation
    纯化方法 Double affinity purification over both non-phospho-peptide column followed by phopshorylated peptide column.
    UniProt编号
    • Q13153
    UniProt汇总 FUNCTION: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
    SIZE: 545 amino acids; 60647 Da
    ENZYME REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-423 and allows the kinase domain to adopt an active structure. Also activated by binding to GTP-bound CDC42, independent of the phosphorylation state of Thr-423. Phosphorylation of Thr-84 by OXSR1 inhibits this activation
    SUBUNIT: Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK.
    SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation.
    PTM: Autophosphorylated when activated by CDC42/p21 and RAC1.
    SIMILARITY: SwissProt: Q13153 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by western blot on untreated and pervanadate-treated Jurkat cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,09-258,Anti-phospho-PAK1 (Ser199/Ser204) Antibody

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