merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2290B,Anti-MAP-2 Antibody, Biotin Conjugate,AB2290B

  • merck millipore,默克密理博,AB2290B,Anti-MAP-2 Antibody, Biotin Conjugate,AB2290B

    产品名称：Anti-MAP-2 Antibody, Biotin Conjugate, AB2290B
    产品型号：AB2290B


    merck millipore,默克密理博,AB2290B,Anti-MAP-2 Antibody, Biotin Conjugate,AB2290B

  • 产品介绍
  • merck millipore,默克密理博,AB2290B,Anti-MAP-2 Antibody, Biotin Conjugate,AB2290B

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, RIHCRbBiotinPolyclonal Antibody
    描述
    产品目录编号 AB2290B
    描述 Anti-MAP-2 Antibody, Biotin Conjugate | AB2290B
    Alternate Names
    • MAP-2
    • Microtubule-associated protein 2
    背景信息 The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
    产品信息
    格式 Biotin
    控制
    • Adult mouse brain tissue
    演示 Purified rabbit polyclonal conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA..
    应用
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected MAP-2 in paraffin sections of adult mouse brain tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to rat MAP-2.
    宿主 Rabbit
    品种反应性 MouseRat
    Species Reactivity Note Demonstrated to react with Rat and Mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037198
    Entrez基因汇总 Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD].
    基因符号
    • Mtap2
    • Map2
    纯化方法 Affinity purified
    UniProt编号
    • P15146
    UniProt汇总 FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

    SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable.

    DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. MAP2A/c is phosphorylated.

    SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in adult mouse brain tissue.

    Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAP-2 in cryosections of adult mouse brain tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB2290B,Anti-MAP-2 Antibody, Biotin Conjugate,AB2290B

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