merck millipore,默克密理博,287891,5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0

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merck millipore,默克密理博,287891,5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
产品名称：5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
产品型号：287891
A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM).

merck millipore,默克密理博,287891,5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem

产品介绍

merck millipore,默克密理博,287891,5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem

重要规格表

经验配方	CAS号
C₁₂H₁₂Cl₂N₂O₄	53-85-0

描述
概述	A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G₁/S cell cycle arrest.
产品目录编号	287891
品牌系列	Calbiochem®
同义词	5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII

参考
参考	Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681. Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284. Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806. Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414. Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461. Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561. Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167. Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.

参考

Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.

产品信息
CAS号	53-85-0
具有ATP竞争性	Y
形式	White solid
Hill配方	C₁₂H₁₂Cl₂N₂O₄
化学配方	C₁₂H₁₂Cl₂N₂O₄
Molar Mass	319.2
可逆	N
结构配方图像

生物信息
主靶	casein kinase II
主靶IC₅₀	6 µM
纯度	≥98% by TLC

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

GHS安全信息
RTECS	DD7310000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Room temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.