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merck millipore,默克密理博,MABF117,Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1
产品名称：Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1
产品型号：MABF117
Detect Myeloid differentiation-2 (MD-2) using this Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1 validated for use in FC, IC, WB, ELISA.
merck millipore,默克密理博,MABF117,Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, FC, ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABF117 描述 Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1 Alternate Names - Protein MD-2
- Lymphocyte antigen 96
- Ly-96
- ESOP-1
背景信息 Myeloid Differentiation-2 (MD-2) is a small secreted glycoprotein that binds with cytokine-like affinities to both the hydrophobic portion of lipopolysaccharides (LPS) and the extracellular domain of Toll-like Receptor 4 (TLR4). TLR-4 is activated by its natural ligand(s), the presence of extracellular MD-2, and most lipopolysaccharides (glycan complexes which may be produced by Gram-negative bacteria). MD-2 also interacts with TLR2 in response to cell wall components of Gram-positive and Gram-negative bacteria. 产品信息 格式 Purified 控制 - PBMC cells.
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Detect Myeloid differentiation-2 (MD-2) using this Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1 validated for use in FC, IC, WB, ELISA. 主要应用 - ELISA
- Flow Cytometry
- Immunocytochemistry
- Western Blotting
应用说明 Flow Cytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocytes and HEK293 cells stably expressing Flag-tagged MD2. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)
Immunocytometry Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in human monocites. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)
Western Blot Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in CHO cell lysates expressing MD2 and Flag-tagged MD2 (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)
ELISA Analysis: A representative lot from an independent laboratory detected Myeloid differentiation-2 in supernatent from unstimulated and IL-10 stimulated human monocytes. (Sandanger, Ø, et al. (2009). J Immunol. 182(1):588-595.)生物信息 免疫原品种 Mouse MD-2 and HEK293 cells stably expressing TLR4 and MD-2. 克隆 IIC1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001182726
Entrez基因汇总 This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. 基因符号 - MD2
- LY96
- ESOP1
纯化方法 Purified by ion-exchange chromatography UniProt编号 - Q9Y6Y9
UniProt汇总 FUNCTION: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
SUBUNIT STRUCTURE: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.
SUBCELLULAR LOCATION: Secreted › extracellular space.产品使用声明 质量保证 Evaluated by Flow Cytometry in PBMC cells.
Flow Cytometry Analysis: 1 µg/mL of this antibody detected Myeloid differentiation-2 in 1X10E5 PBMC cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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