merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5032,Anti-Neural Cell Adhesion Molecule Antibody

  • merck millipore,默克密理博,AB5032,Anti-Neural Cell Adhesion Molecule Antibody

    产品名称：Anti-Neural Cell Adhesion Molecule Antibody
    产品型号：AB5032
    Detect Neural Cell Adhesion Molecule using this Anti-Neural Cell Adhesion Molecule Antibody validated for use in ELISA, IF, IH, FUNC & WB.

    merck millipore,默克密理博,AB5032,Anti-Neural Cell Adhesion Molecule Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5032,Anti-Neural Cell Adhesion Molecule Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Ch, H, MWB, ELISA, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5032
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neural Cell Adhesion Molecule Antibody
    Alternate Names
    • antigen recognized by monoclonal antibody 5.1H11
    • CD56 antigen
    背景信息 The Immunoglobulin superfamily of cell adhesion molecules is related to the immunoglobulins proteins by structure. The family contains over a 100 members, which include ICAM (intercellular adhesion molecule), NCAM (neural cell adhesion molecule) and NgCAM (neural-glial cell adhesion molecule). Both NCAM and NgCAM are calcium independent adhesion molecules. NCAM, the first CAM to be characterized, is expressed on all neurons from very early in development. It binds homophilically to NCAM on adjacent cells and has a variety of functions during neural development. One of these important functions is to hold developing neurites together during neuron outgrowth and formation of neural connections. The adhesive properties of NCAM are modulated during development and plasticity by the presence of the regulated carbohydrate, polysialic acid (PSA). The post-translational addition of alpha-2,8-linked PSA (NCAM-PSA) appears to contribute to synaptic plasticity during learning and memory formation and to the mechanisms of nerve regeneration.
    产品信息
    格式 Affinity Purified
    控制
    • Neuraminidase-treated mouse brain membrane.
    演示 Purified rabbit polyclonal in buffer containing PBS containing no preservatives.
    应用
    应用 Detect Neural Cell Adhesion Molecule using this Anti-Neural Cell Adhesion Molecule Antibody validated for use in ELISA, IF, IH, FUNC & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    A previous lot was shown to work with a wide range of fixatives. Will detect chicken NCAM using a concentration of 1 μg/mL and mouse NCAM using a concentration of 2 μg/mL.

    Immunofluorescence:
    A previous lot of this antibody was used in Immunofluorescence.

    Function blocking:
    A previous lot of this antibody was used in Function blocking.

    ELISA:
    0.3 μg/mL of a previous lot was used.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Highly purified chicken NCAM
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Neural Cell Adhesion Molecule (NCAM). MW is 200-250 kDa; when treated with Neuraminidase, 140-180 kDa. A breakdown product of 160 kDa may also be visible.
    品种反应性 RatChickenHumanMouse
    Species Reactivity Note Mouse. Expected to cross-react with Chicken, Human, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_181351.3
    • NM_000615.5
    • NM_001076682.2
    基因符号
    • NCAM1
    • CD56
    • NCAM
    • MSK39
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P13592
    UniProt汇总 FUNCTION: SwissProt: P13592 # This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.| P13591 # This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
    SIZE: 761 amino acids; 83770 Da
    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
    DOMAIN: SwissProt: P13592
    SIMILARITY: SwissProt: P13592 ## Contains 2 fibronectin type-III domains. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. | P13591 ## Contains 2 fibronectin type-III domains. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on mouse brain lysates.

    Western Blot Analysis: 1:1000 dilution of this lot detected NCAM on 10 μg of mouse brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.

    Handling Recommendations:
    Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5032,Anti-Neural Cell Adhesion Molecule Antibody

上一件merck millipore产品：merck millipore,默克密理博,FCMAB218F,Milli-Mark Anti-CD19-FITC Antibody, clone 6D5
下一件merck millipore产品：merck millipore,默克密理博,MABF117,Anti-Myeloid differentiation-2 (MD-2) Antibody, clone IIC1


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