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描述 产品目录编号 12-556 品牌系列 Upstate
商名 - Upstate
描述 Cofilin 1 概述 N-terminal GST-tagged recombinant human, full length cofilin 1 应用 应用 Cofilin 1 primarily used in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005507.2
Entrez基因汇总 Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM] 基因符号 - p18
- CFL1
- CFL
- Cofilin-1
纯化方法 Glutathione-agarose UniProt编号 - P23528
UniProt汇总 FUNCTION: SwissProt: P23528 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
SIZE: 166 amino acids; 18502 Da
SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
TISSUE SPECIFICITY: Widely distributed in various tissues.
PTM: Phosphorylated on Ser-3 in resting cells (By similarity).
SIMILARITY: SwissProt: P23528 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain.产品使用声明 质量保证 Routinely evaluated as a substrate in a kinase assay using LIM Kinase 1 (Catalog# 14-656). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 150 µg
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