merck millipore,默克密理博,ABN308,Anti-DISC1 Antibody

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H, R	WB, IHC, ICC	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABN308
描述	Anti-DISC1 Antibody
Alternate Names	Disrupted in schizophrenia 1
背景信息	Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

产品信息
格式	Affinity Purified
控制	Human brain tissue
演示	Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

应用
应用	Anti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.
主要应用	Western Blotting Immunohistochemistry Immunocytochemistry
应用说明	Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in rat cerebellum tissue. Immunocytochemistry Analysis: A 1:2,000 dilution from a representative lot detected DISC1 in HeLa cells. Western Blot Analysis: 2 µg/mL from a representative lot detected DISC1 in 10 µg/mL of SK-N-SH cell lysate and mouse brain tissue lysate.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human DISC1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	MouseHumanRat
Species Reactivity Note	Demonstrated to react with Human, Mouse, and Rat.
抗体类型	Polyclonal Antibody
基因符号	DISC1
纯化方法	Antigen Affinity purified
UniProt编号	Q9NRI5

产品使用声明
质量保证	Evaluated by Immunohistochemistry in human brain tissue. Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in human brain tissue.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABN308,Anti-DISC1 Antibody

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech