merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1416,Anti-4E-BP1 Antibody

  • merck millipore,默克密理博,07-1416,Anti-4E-BP1 Antibody

    产品名称：Anti-4E-BP1 Antibody
    产品型号：07-1416
    Anti-4E-BP1 Antibody detects level of 4E-BP1 & has been published & validated for use in WB, IH(P).

    merck millipore,默克密理博,07-1416,Anti-4E-BP1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1416,Anti-4E-BP1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, H, R, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1416
    Replaces 04-321
    描述 Anti-4E-BP1 Antibody
    产品信息
    格式 Affinity Purified
    控制
    • A431 cell lysate
    演示 Purified rabbit polyclonal IgG in buffer containing Tris-citrate/phosphate, pH 7-8, and 0.1% sodium azide.
    应用
    应用 Anti-4E-BP1 Antibody detects level of 4E-BP1 & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemisty (paraffin): 4E-BP1 representative staining pattern/morphology in thyroid cancer. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining pattern/morphology in thyroid cancer tissue.

    Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet.
    生物信息
    免疫原品种 Synthetic peptide corresponding to a portion of human eIF4E Binding Protein encoded in part by exon 2 and 3.
    宿主 Rabbit
    特异性 Eukaryotic translation initiation factor 4E binding protein (eIF4E Binding Protein, eIF4EBP1, 4E-BP1, 4EBP1).
    同种型 IgG
    品种反应性 PigHumanRatMouse
    Species Reactivity Note Human, Rat, Mouse and Pig.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004095.3
    Entrez基因汇总 This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in sponse to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.[provided by RefSeq]
    基因符号
    • BP-1
    • EIF4EBP1
    • PHAS-I
    • MGC4316
    • 4E-BP1
    • 4EBP1
    纯化方法 Affinity Purfied
    UniProt编号
    • Q13541
    UniProt汇总 FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
    SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.
    PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: Belongs to the eIF4E-binding protein family.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on A431 lysates.

    Western Blot Analysis:
    1:500-1:1,000 dilution of this lot detected 4E-BP1 on 10 μg of A431 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1416,Anti-4E-BP1 Antibody

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