merck millipore,默克密理博,MABE481,Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABE481,Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody
产品名称：Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody
产品型号：MABE481
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABE481,Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABE481,Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABE481
描述	Anti-Lamin A/C, clone EP4520, Rabbit Monoclonal Antibody
Alternate Names	Prelamin-A/C
背景信息	Prelamin-A/C, also known as Lamin-A/C, and encoded by the gene name LMNA or LMN1, is a member of the intermediate filament family. Nuclear lamins are composed of the type V intermediate filament proteins. Often referred to as nucleoskeletal proteins they play a key role in nuclear integrity, positioning of nuclear pores, and overall nuclear size and shape. They also play several key functional roles in the maintenance and propagation of the genome--replication, transcription-- as well as the disassembly and reassembly of the nucleus during cell division. In vitro studies have shown that dimers are the basic building blocks of higher order lamin structures and in low concentrations lamins are distributed throughout the nucleoplasm. In humans, there are two types of lamins: A-type lamins (lamins A and C), found primarily in differentiated cells, and B-type lamins (lamins B1 and B2), found in all nucleated cells. Nuclear lamins are involved in a number of essential nuclear functions, including nuclear envelope assembly and disassembly during cell division, DNA synthesis, transcription, and apoptosis. Nuclear lamins have been found to co-localize with DNA synthesis sites.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected Lamin A/C in human breast tissue. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human Lamin A/C.
克隆	EP4520
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
特异性	This antibody recognizes full length Lamin A/C and the cleaved large unit.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	LMN1 LMNA
纯化方法	Unpurified
UniProt编号	P02545

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa treated with staurosporine, HeLa, Jurkat, HeLa treated with camptothecine, and HeLa cell lysates. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected Lamin A/C in HeLa treated with staurosporine, HeLa, Jurkat, HeLa treated with camptothecine, and HeLa cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.