merck millipore,默克密理愽
  • merck millipore,默克密理博,06-891,Anti-SMRTe Antibody

  • merck millipore,默克密理博,06-891,Anti-SMRTe Antibody

    产品名称：Anti-SMRTe Antibody
    产品型号：06-891
    Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.

    merck millipore,默克密理博,06-891,Anti-SMRTe Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-891,Anti-SMRTe Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ICCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-891
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-SMRTe Antibody
    背景信息 SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
    产品信息
    格式 Purified
    控制
    • Mouse brain nuclear extract
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 GST fusion-protein corresponding to residues 1146-1349 of human SMRTe
    宿主 Rabbit
    特异性 SMRT isoforms
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_006312
    基因符号
    • N-CoR2
    • NCOR2
    • SMRTE
    • TRAC-1
    • CTG26
    • SMRTe
    • TNRC14
    • SMRT
    • TRAC1
    • SMAP270
    • SMRTE-tau
    • TRAC
    纯化方法 Protein A chromatography
    UniProt编号
    • Q9Y618
    UniProt汇总 FUNCTION: SwissProt: Q9Y618 # Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
    SIZE: 2517 amino acids; 274034 Da
    SUBUNIT: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. The SRMT isoform interacts with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Ubiquitous. High levels of expression are detected in lung, spleen and brain.
    DOMAIN: SwissProt: Q9Y618 The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor- interacting domains that are divided in two separate interaction domains (ID1 and ID2). & The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
    SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. & Contains 2 SANT domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on nuclear fraction from murine brain
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-891,Anti-SMRTe Antibody

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