merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE320,Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

  • merck millipore,默克密理博,MABE320,Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

    产品名称：Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1
    产品型号：MABE320
    This Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1 is validated for use in Western Blotting, Flow Cytometry, Immunoprecipitation, Immunofluorescence for the detection of c-ErbB2/c-Neu (Ab-5).

    merck millipore,默克密理博,MABE320,Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

  • 产品介绍
  • merck millipore,默克密理博,MABE320,Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE320
    Replaces 04-1127
    描述 Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1
    Alternate Names
    • CD340
    • Receptor tyrosine-protein kinase erbB-2
    • Metastatic lymph node gene 19 protein
    • MLN 19
    • Proto-oncogene Neu
    • Proto-oncogene c-ErbB-2
    • Tyrosine kinase-type cell surface receptor HER2
    • p185erbB2
    背景信息 The ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. ErbB2 dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer.
    产品信息
    格式 Purified
    控制
    • SK-BR-3 cells
    演示 Purified mouse monoclonal IgG1κ cultured supernatent in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1 is validated for use in Western Blotting, Flow Cytometry, Immunoprecipitation, Immunofluorescence for the detection of c-ErbB2/c-Neu (Ab-5).
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005). Cancer Res. 65(2):650-656.).

    Western Blot Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005). Cancer Res. 65(2):650-656.).

    Immunoprecipitation Analysis: A representative lot from an independent laboratory precipitated c-ErbB2/c-Neu in IP (McKenzie, S. J., et al. (1989). 4(5):543-548.).

    Immunofluorescence Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in IF (McKenzie, S. J., et al. (1989). 4(5):543-548.).
    生物信息
    免疫原品种 Cells overexpressing human c-ErbB2/c-Neu
    表位 Extracellular domain
    克隆 TA-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the extracellular domain of ErbB2/c-Neu.
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001005862
    基因符号
    • NGL
    • ERBB2
    • HER2
    • MLN19
    • NEU
    纯化方法 Protein G purified
    UniProt编号
    • P04626
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in SK-BR-3 cells.

    Flow Cytometry Analysis: 0.5 µg of this antibody detected c-ErbB2/c-Neu in 0.5X10E6 SK-BR-3 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE320,Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1

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