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经验配方 CAS号 C₂₁H₁₈NO₄Cl 3895-92-9 描述 概述 Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. 产品目录编号 220285 品牌系列 Calbiochem®
参考 参考 Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.产品信息 CAS号 3895-92-9 具有ATP竞争性 N 形式 Light yellow to yellow solid Hill配方 C₂₁H₁₈NO₄Cl 化学配方 C₂₁H₁₈NO₄Cl Molar Mass 383.8 可逆 N 结构配方图像 生物信息 主靶 PKC 主靶IC50 660 nM 纯度 ≥97% by NMR 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O GHS安全信息 RTECS FL9200000 安全信息 R相 R: 20/21/22-36/37/38
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
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