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品种反应性 主要应用 宿主 格式 抗体类型 R, H, Ht, M WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 06-591 Replaces AB3823 品牌系列 Upstate
商名 - Upstate
描述 Anti-Caveolin Antibody 概述 As Caveolin is an integral membrane protein, the use of membrane preparations may enhance detection 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.5, and 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-Caveolin Antibody is an antibody against Caveolin for use in IC, IP & WB. 主要应用 - Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 Partial fusion protein corresponding to amino acids 1-101 of human Caveolin 宿主 Rabbit 特异性 α-isoform of Caveolin 同种型 IgG 品种反应性 RatHumanHamsterMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001753
Entrez基因汇总 The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. 基因符号 - MSTP085
- CAV1
- CAV
- VIP21
- Caveolin-1.
纯化方法 Protein A chromatography UniProt编号 - Q03135
UniProt汇总 FUNCTION: SwissProt: Q03135 # May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
SIZE: 178 amino acids; 20472 Da
SUBUNIT: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane.
TISSUE SPECIFICITY: In muscle and lung, less so in liver, brain and kidney.
PTM: The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
SIMILARITY: SwissProt: Q03135 ## Belongs to the caveolin family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from EGF stimulated A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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