merck millipore,默克密理博,MABE251,Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
A	ELISA	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABE251
描述	Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31
背景信息	5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base formed from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of iron-dependent oxygenases. Data suggests that every mammilian cell contains 5-hydroxymethylcytosine, but the levels vary depending on the cell type; data also suggests that levels of 5-hydroxymethylcytosine increases with age. The highest levels are found in neuronal cells of the central nervous system and certain mammalian tissues such as mouse Purkinje and granule neurons. Although the exact function has not been fully elucidated, studies suggest that 5-hydroxymethlcytosine may regulate gene expression or initiate DNA demethylation.

产品信息
格式	Purified
控制	Unmodified and modified cytosine DNA.
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect 5-hydroxymethylcytosine (5hmC) with Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31 (Mouse Monoclonal Antibody), that has been shown to work in DB, MeDIP, ELISA.
主要应用	ELISA
应用说明	ELISA Analysis: A representative lot detected 5-hydroxymethylcytosine in ELISA. Methylated DNA Immunoprecipitation (MeDIP) Analysis: A representative lot immunoprecipitated 5-hydroxymethylcytosine in ChIP.

生物信息
免疫原品种	BSA-conjugated 5-hydroxymethylcytosine.
表位	5-hydroxymethylcytosine
克隆	HMC 31
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody recognizes the 5-hydroxymethylcytosine of 5-Hydroxymethylcytosine DNA.
同种型	IgG1κ
品种反应性	All
Species Reactivity Note	Reacts with all species
抗体类型	Monoclonal Antibody
Entrez基因编号	N/A
纯化方法	Protein G purified
UniProt编号	NA

产品使用声明
质量保证	Evaluated by Dot Blot in unmodified and modified cytosine DNA. Dot Blot Analysis: 0.1 µg/mL of this antibody detected 5-hydroxymethylcytosine in 10 ng and 50 ng of unmodified and modified cytosine DNA.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABE251,Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone HMC 31

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