merck millipore,默克密理博,492031,NS8593

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merck millipore,默克密理博,492031,NS8593 - Calbiochem
产品名称：NS8593 - Calbiochem
产品型号：492031
An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.

merck millipore,默克密理博,492031,NS8593 - Calbiochem

产品介绍

merck millipore,默克密理博,492031,NS8593 - Calbiochem

重要规格表

经验配方
C₁₇H₁₇N₃

描述
概述	An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; K_d = 420 nM, 600 nM, and 730 nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC₅₀ = 1.6 mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture.
产品目录编号	492031
品牌系列	Calbiochem®
同义词	(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine

参考
参考	Chubanov, V., et al. 2012. Brit. Journ. Pharm. 166, 1357. Jenkins, D., et al. 2011. Hypertension. 57, 1129. Jenkins, D., et al. 2011. Mol. Pharm. 79, 899. Jenkins, D., et al. 2011. Mol. Pharm. 79, 899. Lasse, S., et al. 2011. J. Cardiov. Pharm. 57, 672. Diness, J., et al. 2010. Circ Arrhythm Electrophusiol. 3, 380. Ji, H., et al. 2009. Eur. J. Neurosci. 9, 1883. Strobaek, D., et al. 2006. Mol. Pharm. 70, 1771.

参考

Chubanov, V., et al. 2012. Brit. Journ. Pharm. 166, 1357.
Jenkins, D., et al. 2011. Hypertension. 57, 1129.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Lasse, S., et al. 2011. J. Cardiov. Pharm. 57, 672.
Diness, J., et al. 2010. Circ Arrhythm Electrophusiol. 3, 380.
Ji, H., et al. 2009. Eur. J. Neurosci. 9, 1883.
Strobaek, D., et al. 2006. Mol. Pharm. 70, 1771.

产品信息
形式	White powder
Hill配方	C₁₇H₁₇N₃
化学配方	C₁₇H₁₇N₃
Molar Mass	263.3
结构配方图像

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.