merck millipore,默克密理博,04-454,Anti-Ubiquitin (CT) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-454,Anti-Ubiquitin (CT) Antibody, rabbit monoclonal
产品名称：Anti-Ubiquitin (CT) Antibody, rabbit monoclonal
产品型号：04-454
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Ubiquitin (C-term) using this Anti-Ubiquitin More>>

merck millipore,默克密理博,04-454,Anti-Ubiquitin (CT) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-454,Anti-Ubiquitin (CT) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-454
品牌系列	Upstate
商名	Upstate
描述	Anti-Ubiquitin (CT) Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Ubiquitin (C-term) using this Anti-Ubiquitin (C-term) Antibody, Rabbit validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic peptide composed of residues at the C-terminus of human Ubiquitin.
宿主	Rabbit
特异性	Recognizes a region composed of residues at the C-terminus of human Ubiquitin.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002954.3
Entrez基因汇总	This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
基因符号	HUBCEP80 RPS27A CEP80 ubiquitin ubiquitin-CEP80 UBCEP1 Ubiquitin. UBA52 UBCEP2 UBA80 UBC UBB
UniProt编号	P62988
UniProt汇总	FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair. SIZE: 76 amino acids; 8565 Da SUBCELLULAR LOCATION: Cytoplasm. Nucleus. PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly. SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family. MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.