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品种反应性 主要应用 宿主 格式 抗体类型 R, M, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS25 描述 Anti-VLDL-R Antibody, clone 6A6 Alternate Names - VLDL receptor
- very low density lipoprotein receptor
- very low-density lipoprotein receptor
背景信息 Very low-density lipoprotein receptor (VLDL-R) belongs to the low density lipoprotein receptor family. VLDL-R binds particles containing apolipoprotein E (apoE) with high affinity. This includes VLDL, which after being bound by VLDL-R is then transported into the cell via endocytosis. It also binds to Reelin, stimulating Dab1 phosphorylation and the regulation of Tau phosphorylation. VLDL-R expression has been observed at high levels in adipose tissue, brain, heart, kidney, ovary, and skeletal muscle. It is not present in the liver. Defects involving deletion of the VLDL-R sequence are thought to be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH also known as DES), a cerebellar disorder characterized by delayed ambulation, moderate to severe mental retardation, primarily truncal ataxia. 产品信息 格式 Purified 控制 - Mouse fetal brain tissue lysate
演示 Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-VLDL-R Antibody, clone 6A6 is an antibody against VLDL-R for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human VLDL-R. 表位 C-terminus 克隆 clone 6A6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes VLDL-R at the C-terminus. 同种型 IgG1λ 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human and rat based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001018066
Entrez基因汇总 The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq]. 基因符号 - VLDLR
- VLDLRCH
- VLDL-R
- CARMQ1
- CHRMQ1
纯化方法 Protein G UniProt编号 - P98155
UniProt汇总 FUNCTION: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
SUBUNIT STRUCTURE: Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane › clathrin-coated pit; Single-pass type I membrane protein.
TISSUE SPECIFICTY: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
INVOLVEMENT IN DISEASE: Deletions involving VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. VLDLRCH is a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia. Additional features include strabismus and pesplanus in the majority of patients, seizures in 40% of patients, and short stature in 15% of patients. Magnetic resonance imaging demonstrates inferior cerebellar hypoplasia and mild cortical gyral simplification.
SEQUENCE SIMILARITIES: Contains 3 EGF-like domains.
Contains 8 LDL-receptor class A domains.
Contains 6 LDL-receptor class B repeats.产品使用声明 质量保证 Evaluated by Western Blot in mouse fetal brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VLDL-R on 10 µg of mouse fetal brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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