merck millipore,默克密理愽
  • merck millipore,默克密理博,662141,DUB Inhibitor V, PR-619 - Calbiochem

  • merck millipore,默克密理博,662141,DUB Inhibitor V, PR-619 - Calbiochem

    产品名称：DUB Inhibitor V, PR-619 - Calbiochem
    产品型号：662141
    The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,662141,DUB Inhibitor V, PR-619 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,662141,DUB Inhibitor V, PR-619 - Calbiochem

    重要规格表

    经验配方
    C₇H₅N₅S₂
    描述
    概述 A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains.
    产品目录编号 662141
    品牌系列 Calbiochem®
    同义词 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine, PR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I
    参考
    参考 Altun, M., et al. 2011. Chem. Biol. 18, 1401.
    Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165.
    产品信息
    形式 Beige solid
    Hill配方 C₇H₅N₅S₂
    化学配方 C₇H₅N₅S₂
    Molar Mass 223.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,662141,DUB Inhibitor V, PR-619 - Calbiochem

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