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merck millipore,默克密理博,MABD163,Anti-LIN28 Antibody, clone 6D1F9
产品名称：Anti-LIN28 Antibody, clone 6D1F9
产品型号：MABD163
Detect lin28 using this mouse monoclonal antibody, Anti-LIN28 Antibody, clone 6D1F9 validated for use in western blotting & Immunofluorescence.
merck millipore,默克密理博,MABD163,Anti-LIN28 Antibody, clone 6D1F9
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABD163 描述 Anti-LIN28 Antibody, clone 6D1F9 Alternate Names - Zinc finger CCHC domain-containing protein 1
- Protein lin-28 homolog A
- Lin-28A
背景信息 Lin28 is a developmentally regulated RNA binding protein (RBP). Its down regulation is mediated in part by Lin4 and miR-125b, the mammalian micro-RNA homolog of Lin4. It is known to be negatively regulated by retinoic acid and act as a translational enhancer by driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis by increasing the number of initiation events per mRNA molecule. Lin28 is necessary and sufficient for selectively blocking the cleavage processing of pri-let-7 miRNAs in embryonic cells. Lin28 is a negative regulator of miRNA biogenesis and may play a role in blocking miRNA-mediated differentiation in stem cells and in certain cancers. The mechanism by which miR-125b represses Lin28 in mammalian cells appears to involve reductions not only in translational efficiency, but also in mRNA abundance. Lin28 has shown to be essential for skeletal muscle differentiation through the translational upregulation of IGF2 expression. It is known to be expressed in testis, placenta, and embryonic stem (ES) cells. 产品信息 格式 Purified 控制 - NTERA-2 cell lysate
演示 Purified mouse monoclonal liquid in 0.01M Phosphate buffer, pH 7.4 containing up to 0.1% sodium azide. 应用 应用 Detect lin28 using this mouse monoclonal antibody, Anti-LIN28 Antibody, clone 6D1F9 validated for use in western blotting & Immunofluorescence. 主要应用 - Western Blotting
应用说明 Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected LIN28 in NTERA-2 cells.
Optimal working dilutions must be determined by end user.
生物信息 免疫原品种 Purified recombinant fragment of human LIN28 expressed in E. Coli. 克隆 6D1F9 宿主 Mouse 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - ZCCHC1
- LIN28A
- CSDD1
- LIN28
纯化方法 Protein G purified UniProt编号 - Q9H9Z2
产品使用声明 质量保证 Evaluated by Western Blotting in NTERA-2 cell lysate.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected LIN28 in NTERA-2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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