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merck millipore,默克密理博,565763,γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem
产品名称：γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem
产品型号：565763
The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,565763,γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₂₂FNO₂S 287196-57-0 描述 概述 Cell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase. 产品目录编号 565763 品牌系列 Calbiochem®
同义词 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide 参考 参考 Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297. 产品信息 CAS号 287196-57-0 具有ATP竞争性 N 形式 White solid Hill配方 C₁₆H₂₂FNO₂S 化学配方 C₁₆H₂₂FNO₂S Molar Mass 311.1 可逆 N 结构配方图像 生物信息 主靶 Aβ₄₂ production 主靶IC50 1.8 µM against Aβ42 production 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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