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描述 产品目录编号 14-551M 品牌系列 Upstate
商名 - Upstate
描述 Fms Protein, active, 250 µg 概述 N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end 应用 应用 Active, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Human Fms expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005211.2
Entrez基因汇总 The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. 基因符号 - FMS
- CSF1R
- FIM2
- CSF-1-R
- C-FMS
- CSFR
- c-fms
- CD115
蛋白靶 Fms 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - P07333
UniProt汇总 FUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.
SIZE: 972 amino acids; 107984 Da
SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.
SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by phosphorylation of IGF-R1tide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-551) and in bulk (cat# 14-551-K).
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