merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC91,Anti-Atg18 (WIPI-2) Antibody, clone 2A2

  • merck millipore,默克密理博,MABC91,Anti-Atg18 (WIPI-2) Antibody, clone 2A2

    产品名称：Anti-Atg18 (WIPI-2) Antibody, clone 2A2
    产品型号：MABC91
    This Anti-Atg18 (WIPI-2) Antibody, clone 2A2 is validated for use in WB, IH(P) for the detection of Atg18 (WIPI-2).

    merck millipore,默克密理博,MABC91,Anti-Atg18 (WIPI-2) Antibody, clone 2A2

  • 产品介绍
  • merck millipore,默克密理博,MABC91,Anti-Atg18 (WIPI-2) Antibody, clone 2A2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC91
    描述 Anti-Atg18 (WIPI-2) Antibody, clone 2A2
    Alternate Names
    • WIPI49-like protein 2
    • WD repeat domain phosphoinositide-interacting protein 2
    • WIPI-2
    背景信息 Atg18, also known as WIPI-2, is involved in autophagy by regulating the assembly of mulitprotein complexes by presenting a 7-bladed propeller structure for interactions with phospholipids. Atg18 is a mammalian effector of PtdIns3P and is ubiquitously expressed in a variety of cell lines. Studies show that Atg18 is recruited to early autophagosomal structural formation along with Atg16 and ULK1, and Atg18 is required for the formation of LC3-positive autophagosomes.
    产品信息
    格式 Purified
    控制
    • Human testis tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Atg18 (WIPI-2) Antibody, clone 2A2 is validated for use in WB, IH(P) for the detection of Atg18 (WIPI-2).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Atg18 in human colorectal adenocarcinoma tissue.
    生物信息
    免疫原品种 Linear peptide corresponding to the C-terminus of human Atg18.
    表位 C-terminus
    克隆 2A2
    宿主 Mouse
    特异性 This antibody recognizes Atg18 at the C-terminus.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001028690
    Entrez基因汇总 WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008].
    基因符号
    • WIPI2
    纯化方法 Protein G Purified
    UniProt编号
    • Q9Y4P8
    UniProt汇总 FUNCTION: Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P.

    SUBCELLULAR LOCATION: Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note: Enriched at preautophagosomal structure membranes in response to ptdIns3P.

    TISSUE SPECIFICITY: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. SEQUENCE SIMILARITIES: Belongs to the WD repeat SVP1 family.

    Contains 3 WD repeats.
    产品使用声明
    质量保证 Evaluated by Western Blot in human testis tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Atg18 in 10 µg of human testis tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABC91,Anti-Atg18 (WIPI-2) Antibody, clone 2A2

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