merck millipore,默克密理愽
  • merck millipore,默克密理博,365250,Gö 6976 - CAS 136194-77-9 - Calbiochem

  • merck millipore,默克密理博,365250,Gö 6976 - CAS 136194-77-9 - Calbiochem

    产品名称：Gö 6976 - CAS 136194-77-9 - Calbiochem
    产品型号：365250
    A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC₅₀ = 7.9 nM for rat brain).

    merck millipore,默克密理博,365250,Gö 6976 - CAS 136194-77-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,365250,Gö 6976 - CAS 136194-77-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₁₈N₄O136194-77-9
    描述
    概述 A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available.
    产品目录编号 365250
    品牌系列 Calbiochem®
    同义词 Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
    参考
    参考 Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
    Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
    Martiny-Baron, G.M., et al. 1993. J. Biol. Chem. 268, 9194.
    Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 4674.
    产品信息
    CAS号 136194-77-9
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₂₄H₁₈N₄O
    化学配方 C₂₄H₁₈N₄O
    Molar Mass 378.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 PKC
    主靶IC50 7.9 nM against rat brain PKC; 2.3 nM, 6.2 nM against Ca2+-dependent PKC α-isozyme and PKCβI, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

    merck millipore,默克密理博,365250,Gö 6976 - CAS 136194-77-9 - Calbiochem

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