merck millipore,默克密理愽
  • merck millipore,默克密理博,529627,PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

  • merck millipore,默克密理博,529627,PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

    产品名称：PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem
    产品型号：529627
    The PPIase-Parvulin Inhibitor, also referenced under CAS 64005-90-9, controls the biological activity of PPIase-Parvulin.

    merck millipore,默克密理博,529627,PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,529627,PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₈N₂O₈64005-90-9
    描述
    概述 A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 = ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor.
    产品目录编号 529627
    品牌系列 Calbiochem®
    同义词 PiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
    参考
    参考 Uchida, T., et al. 2003. Chem. Biol. 10, 15.
    产品信息
    CAS号 64005-90-9
    具有ATP竞争性 Y
    形式 Brownish solid
    Hill配方 C₂₂H₁₈N₂O₈
    化学配方 C₂₂H₁₈N₂O₈
    Molar Mass 438.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
    主靶IC50 < 5 µM for anti-proliferative properties against a panel of human cancer cell lines; ~ 1.5 µM inhibiting Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
    纯度 ≥95% by NMR
    理化信息
    细胞可渗透 Y
    溶解度 Chloroform or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,529627,PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

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