merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5446,Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24

  • merck millipore,默克密理博,MAB5446,Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24

    产品名称：Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24
    产品型号：MAB5446
    Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24 detects level of Neurofilament NF-H & has been published & validated for use in ELISA, IP, WB, IH.

    merck millipore,默克密理博,MAB5446,Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24

  • 产品介绍
  • merck millipore,默克密理博,MAB5446,Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HIHC, ELISA, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB5446
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24
    产品信息
    格式 Ascites
    控制
    • Positive Control: Brain
    演示 Ascites fluid. Liquid.
    应用
    应用 Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24 detects level of Neurofilament NF-H & has been published & validated for use in ELISA, IP, WB, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Western blot. Reacts with the 200 kD NF-H from human.

    Immunohistochemistry. The antibody has been used successfully on Bouin's and alcohol-fixed paraffin-embedded or frozen tissue sections. Formalin-fixed paraffin-embedded tissue sections require pretreatment with trypsin.

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Rat Neurofilaments
    表位 tail domain (Phosphate dependent)
    克隆 RMO-24
    宿主 Mouse
    特异性 Reacts with Neurofilament Heavy (NF-H), tail domain (phosphate dependent). Dephosphorylation of the NF-H will results in diminished immunoreactivity.
    同种型 IgG1κ
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_021076.2
    基因符号
    • KIAA0845
    • NEFH
    • NFH
    • NF-H
    UniProt编号
    • P12036
    UniProt汇总 FUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
    SIZE: 1026 amino acids; 112480 Da
    PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
    DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB5446,Anti-Neurofilament NF-H Antibody, tail domain (Phosphate dependent), clone RMO-24

上一件merck millipore产品：merck millipore,默克密理博,07-624,Anti-hSNF2H Antibody
下一件merck millipore产品：merck millipore,默克密理博,ABT108,Anti-Lnk/SH2B adapter protein 3 Antibody


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