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  • merck millipore,默克密理博,ABE27,Anti-acetyl-c-Myc (Lys157) Antibody

  • merck millipore,默克密理博,ABE27,Anti-acetyl-c-Myc (Lys157) Antibody

    产品名称：Anti-acetyl-c-Myc (Lys157) Antibody
    产品型号：ABE27
    Anti-acetyl-c-Myc (Lys157) Antibody is a rabbit polyclonal antibody for detection of acetyl-c-Myc (Lys157) also known as HLHe39, Proto-oncogene c-Myc, Transcription factor p64, c-MYC & has been valida More>>

    merck millipore,默克密理博,ABE27,Anti-acetyl-c-Myc (Lys157) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE27,Anti-acetyl-c-Myc (Lys157) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE27
    描述 Anti-acetyl-c-Myc (Lys157) Antibody
    Alternate Names
    • c-MYC
    • Myc proto-oncogene protein
    • Class E basic helix-loop-helix protein 39
    • HLHe39
    • Proto-oncogene c-Myc
    • Transcription factor p64
    背景信息 c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell growth, differentiation, and proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling. c-Myc is itself acetylated on lysine 323 by GCN5, and on lysine 148 and 157 by p300/CBP. The significance of c-Myc acetylation is still under investigation; however, previous studies have suggested that HAT-dependent acetylation of c-Myc may regulate its turnover and stability. c-Myc may play a role in various cancers such as Burkitt’s lymphoma.
    产品信息
    格式 Affinity Purified
    控制
    • Transfected HEK293T cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-acetyl-c-Myc (Lys157) Antibody is a rabbit polyclonal antibody for detection of acetyl-c-Myc (Lys157) also known as HLHe39, Proto-oncogene c-Myc, Transcription factor p64, c-MYC & has been validated in WB, PIA.
    主要应用
    • Western Blotting
    应用说明 Peptide Inhibition Assay Analysis: 0.1 µg/mL from a representative lot blocked acetyl-c-Myc (Lys157) in HEK293T cells co-transfected with wildtype c-Myc and P300.

    Peptide Inhibition Assay Analysis: A representative lot was used by an independent laboratory in HEK293T cells co-transfected with mouse wildtype c-Myc and P300. (Image courtesy of Dr. Ernest Martinez, Department of Biochemistry, University of California at Riverside.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human c-Myc acetylated at Lys157.
    表位 Acetylated Lys157
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes c-Myc acetylated at Lys157 in human and Lys158 in mouse.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Mouse and Human. Predicted to react with Feline, Rhesus Macaque, Chimpanzee, Canine, and Pocine, based on 100% sequence homology. Other homologies: Rat (82% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002458
    基因符号
    • BHLHE39
    • MYC
    纯化方法 Affinity purified
    UniProt编号
    • P01106
    产品使用声明
    质量保证 Evaluated by Western Blot in transfected HEK293T cell lysates.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected c-Myc on 10 µg of transfected HEK293T cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE27,Anti-acetyl-c-Myc (Lys157) Antibody

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