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merck millipore,默克密理博,05-521,Anti-TRF2 Antibody, clone 4A794
产品名称：Anti-TRF2 Antibody, clone 4A794
产品型号：05-521
Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.
merck millipore,默克密理博,05-521,Anti-TRF2 Antibody, clone 4A794
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-521 品牌系列 Upstate
商名 - Upstate
描述 Anti-TRF2 Antibody, clone 4A794 背景信息 TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis. 产品信息 格式 Purified 控制 - Positive Control Included: Jurkat cell lysate (12-303)
演示 Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 150mM Tris/glycine, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30% 应用 应用 Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB. 主要应用 - Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus 克隆 4A794 宿主 Mouse 特异性 Recognizes TRF2. 同种型 IgG1 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005652
Entrez基因汇总 This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. 基因符号 - TRBF2
- TERF2
- TRF2
纯化方法 Protein G purfied UniProt编号 - Q15554
UniProt汇总 FUNCTION: SwissProt: Q15554 # Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle.
SIZE: 500 amino acids; 55551 Da
SUBUNIT: Homodimer. Binds to RAP1. Interacts with NBN.
SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: Q15554 ## Contains 1 HTH myb-type DNA-binding domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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