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merck millipore,默克密理博,FCMAB118P,Milli-Mark™ Anti-CD45 Antibody, clone F10-89.4, PE Conjugate
产品名称：Milli-Mark™ Anti-CD45 Antibody, clone F10-89.4, PE Conjugate
产品型号：FCMAB118P
Milli-Mark Anti-CD45 Antibody, clone F10-89.4, PE Conjugate is an antibody against CD45 for use in FC.
merck millipore,默克密理博,FCMAB118P,Milli-Mark™ Anti-CD45 Antibody, clone F10-89.4, PE Conjugate
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M Phycoerythrin Monoclonal Antibody 描述 产品目录编号 FCMAB118P 商名 - Milli-Mark
描述 Milli-Mark™ Anti-CD45 Antibody, clone F10-89.4, PE Conjugate Alternate Names - CD45 antigen <br />Leukocyte common antigen precursor <br />SCID due to PTPRC deficiency <br />T200 glycoprotein <br />T200 leukocyte common antigen <br />Human homolog of severe combined immunodeficiency due to PTPRC deficiency <br />Leukocyte-common antigen <br />Protein tyrosine phosphatase, receptor type, C <br />Protein tyrosine phosphatase, receptor type, c polypeptide
背景信息 The CD45 molecules are single chain integral membrane proteins, comprising at least 5 isoforms, ranging from 180 to 220 kDa. They are generated by alternative splicing combinations of three exons (A, B, and C) of the genomic sequence. The non-restricted CD45 antigen, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. All the monoclonal antibodies that belong to the CD45 cluster react with this part of the antigen and are able to recognize all CD45 isoforms. 产品信息 格式 Phycoerythrin 控制 - Jurkat cells.
演示 Purified mouse monoclonal IgG2a conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-CD45 Antibody, clone F10-89.4, PE Conjugate is an antibody against CD45 for use in FC. 主要应用 - Flow Cytometry
应用说明 Working Solution Cells / test Total Reaction Volume 5 μl 5 x 105 Cells / 95 μl PBS 100 μl 10 μl 1 x 106 Cells / 90 μl PBS 100 μl 生物信息 免疫原品种 Purified T cells from human lymph nodes. 表位 Extracellular Domain 克隆 F10-89-4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Antibody recognizes CD45. Extracellular Domain. 同种型 IgG2a 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002838.3
Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. ... 基因符号 - EC 3.1.3.48
- PTPRC
- L-CA
- LCA
- CD45
- LY5
- T200
- Glycoprotein
- B220
- GP180
纯化方法 Protein A purfied UniProt编号 - P08575
UniProt汇总 FUNCTION: SwissProt: P08575 # Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.
SIZE: 1304 amino acids; 147254 Da
SUBUNIT: Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P0产品使用声明 质量保证 Evaluated by flow cytometry using jurkat cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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