merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE886,Anti-B-Myb Antibody, clone LX015.1

  • merck millipore,默克密理博,MABE886,Anti-B-Myb Antibody, clone LX015.1

    产品名称：Anti-B-Myb Antibody, clone LX015.1
    产品型号：MABE886
    Detect B-Myb using this Anti-B-Myb Antibody, clone LX015.1 validated for use in western blotting.

    merck millipore,默克密理博,MABE886,Anti-B-Myb Antibody, clone LX015.1

  • 产品介绍
  • merck millipore,默克密理博,MABE886,Anti-B-Myb Antibody, clone LX015.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE886
    描述 Anti-B-Myb Antibody, clone LX015.1
    Alternate Names
    • Myb-like protein 2
    • Myb-related protein B
    • B-Myb
    背景信息 B-Myb, also known as B-Myb or Myb-like protein 2, and encoded by the gene MYBL2/BMYB, is a transcription factor protein involved in the regulation of cell survival, proliferation and differentiation. B-Myb is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. B-Myb is a component of the DREAM complex (also named LINC complex) that is composed of at least E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 proteins. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22. B-Myb is localized to the nucleus. B-Myb is widely expressed and up regulated in cancer cells. B-Myb is an oncogenic transcription factor involved in G2/M progression and is a key target of anti-cancer therapy.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect B-Myb using this Anti-B-Myb Antibody, clone LX015.1 validated for use in western blotting.
    主要应用
    • Western Blotting
    应用说明 Western Blotting Analysis: A representative lot from an independent laboratory detected U2OS cell lysates expressing B-Myb in U2OS (Chen, X., et al. (2013). Mol Cel Biol. 33(2):227-236.).

    Western Blotting Analysis: A representative lot from an independent laboratory in NIH/3T3 cell lysates and in undifferentiated and differentiated F9 cell lysates (Knight, A. S., et al. (2009). Oncogene. 28(15):1737-1747.).

    Western Blotting Analysis: A representative lot from an independent laboratory in cycling NIH/3T3 and F9 nuclear extracts (Muller, G. A., et al. (2012). Nucleic Acids Res. 40(4):1561-78.).

    Western Blotting Analysis: A representative lot from an independent laboratory detected B-Myb wild-type cycling MEF cell lysates and not in B-Myb wild type G0 phase arrested MEF cell lysates. The same lot also detected B-Myb in G0 phase arrested and in cycling MEF cell lysates inappropriately expressing homozygous mutant B-Myb (Tavner, F., et al. (2007). Oncogene. 26(19): 2727-2735.).
    生物信息
    免疫原品种 Recombinant protein corresponding to human B-Myb.
    克隆 LX015.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002457
    基因符号
    • BMYB
    • MYBL2
    纯化方法 Protein G purified
    UniProt编号
    • P10244
    产品使用声明
    质量保证 Evaluated by Western Blotting in HEK293 cell lysate.

    Western Blotting Analysis: 1 μg/mL of this antibody detected B-Myb in 10 μg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE886,Anti-B-Myb Antibody, clone LX015.1

上一件merck millipore产品：merck millipore,默克密理博,05-668,Anti-phospho-SHC (Tyr317) Antibody, clone 15E11
下一件merck millipore产品：merck millipore,默克密理博,SF-1605,MSI1; Mouse, Cyanine 3 RNA Detection Probe,SmartFlare


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